Willbold Group

Group leader

Title

Name

First Name

Position

Prof. Dr.

Willbold

Dieter

Head of the Institute

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Researchers

Title

Name

First Name

Position

Dr.

Stoldt

Matthias

Senior Scientist

PD Dr.

König

Bernd

Senior Scientist

Dr.

Nagel-Steger

Luitgard

Senior Scientist


BioStruct Fellow

Title

Name

First Name

Position

MSc

Börger

Claudia

Doctoral Researcher

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Further Team Members

Technicians:

5

Master/Diploma students:

2

PHD/MD students:

17


Contact

Dieter Willbold
Institute of Physical Biology
Heinrich Heine University
Universitätsstr. 1
40225 Düsseldorf
Germany

Tel.: +49 211 81-11390
Fax: +49 211 81-15167

website:
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undefinedFZS Jülich

Contact 2

Matthias Stoldt
Institute of Physical Biology
Heinrich Heine University
Universitaetsstr. 1
40225 Duesseldorf
Germany

Tel.: +49 2461 61-5874
Fax: +49 2461 61-2023


Expertise in Structural Biology

  • Liquid NMR-spectroscopy
  • Fluorescence Correlation Spectroscopy (FCS)
  • Analytical Ultracentrifugation
  • Surface Plasmon Resonance Spectroscopy

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Main areas of research interest

  • Structural biology
  • NMR spectroscopy
  • Protein ligand interactions
  • Viral proteins (HIV and SARS-CoV) and their cellular interaction partners
  • Proteins involved in neurodegeneration
  • Approaches to diagnosis and therapy of Alzheimer's disease

Facilities

The laboratories cover the following gene technology security levels:

S1, S2

The laboratories cover the following biohazard levels:

BSL1, BSL2, BSL3**

Laboratory Equipment

General equipment available in the laboratories:

  • Biochemistry
  • Biophysics
  • Cell culture
  • Molecular biology
  • Biotechnology
  • Biocomputing
  • Microbiology
  • Imaging


Special equipment, which is not generally available in most laboratories:

  • NMR-Spectrometers: 3x 600 MHz, 1x 800 MHz, 1x 900 MHz
  • Analytical Ultracentrifuge
  • Dual-Colour Fluorescence Correlation Spectrometer
  • Surface Plasmon Resonance Spectrometer
  • Circular Dichroism Spectrometer
  • Fluorescence Spectrometer
  • Confocal Laser Scanning Microscope
  • Field Flow Fractionation with Multiangle Light Scattering Detection
NMR spectrometer

Non-standard methods, which are established in the laboratory

  • Nanodisc Technology
  • Phage Display Screening
  • Mirror Image Phage Display Screening
  • High Magentic Field NMR Spectrosocpy
  • 2-Dimensional Fluorescence Intensity Distribution Assay (2D-FIDA)

Important References

  • Willbold, D., Rosin-Arbesfeld, R., Sticht, H., Frank, R. & Rösch, P. (1994) Structure of the equine infectious anemia virus Tat protein. Science 264, 1584-1587
  • Rösch, P. & Willbold, D. (1996) Is EIAV Tat protein a homeodomain? Science 272, 1672
  • Schmidt, H., Hoffmann, S., Tran. T., Stoldt, M., Stangler, T., Wiesehan, K. & Willbold, D. (2007) Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes. J. Mol. Biol. 365, 1517-1532.
  • Wittlich, M., König, B. W., Hoffmann, S. & Willbold, D. (2007) Structural characterisation of the transmembrane and cytoplasmic domains of human CD4. BBA Biomem. 3, 2949-2960.
  • Weiergraeber, O. H., Stangler, T., Thielmann, Y., Mohrlüder, J., Wiesehan, K. & Willbold, D. (2008) Ligand binding mode of GABAA receptor-associated protein. J. Mol. Biol., 381, 1320-1331

Cooperators

  • Gordeliy, Victor, Prof. Dr., CEA-CNRS-Université Joseph Fourier in Grenoble, France
  • Korth, Carsten, PD Dr., Institut für Neuropathologie, Universtitätsklinikum Düsseldorf, Germany
  • Schrader, Thomas, Prof. Dr., University Duisburg-Essen, Germany
  • Sticht, Heinrich, Prof. Dr., Friedrich-Alexander University Erlangen-Nürnberg, Germany
  • van Groen, Thomas, Prof. Dr., University of Alabama at Birmingham, USA
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