Stoldt Group

Group leader

Title

Name

First Name

Position

Prof. M.D. Ph.D.

Scharf

Rüdiger E.

Director

Researchers

Title

Name

First Name

Position

Ph.D.

Stoldt

Volker R.

Group leader

Ph.D.

Gyenes

Marianna

Senior scientist


BioStruct Fellow

Title

Name

First Name

Position

MSc

Huynh

Khon C.

PhD student

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Further Team Members

Technicians:

2

PHD/MD students:

6


Contact

Volker R. Stoldt
Dept. of Hemostasis and Transfusion Medicine
Heinrich Heine University Medical Center
Moorenstrasse 5
40225 Düsseldorf
Germany

Tel : +49 211 81-16916
Fax: +49 211 81-19230

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Special Methodical Expertise

  • Flow simulation by in vitro flow models and rheometer
  • Multiparametric confocal laser scanning microscopy and 3D-imaging
  • Multiparametric flow cytometrie and fluorescence imaging

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Main areas of research interest

  • Structure and function of integrins
  • Mechanotransduction and biomechanic stress
  • Protein interactions and cytoskeletal functions/reinforcement

Facilities

The laboratories cover the following gene technology security levels:

S1

The laboratories cover the following biohazard levels:

BSL2

Laboratory Equipment

General equipment available in the laboratories:

  • Biochemistry
  • Cell culture
  • Molecular biology
  • Immunology
  • Cell Biology
  • Imaging


Special equipment, which is not generally available in most laboratories:

  • multiparametric confocal laser scanning microscope, multiparametric flow cytometer


Non-standard methods, which are established in the laboratory:

  • in vitro flow models combined with diverse fluorescence imaging systems

Important References

  • Stoldt VR, Peveling J, Loncar R, Beck A, Aurich V, Scharf RE. (2005) Evaluation of platelet thrombus formation under flow. Blood, 106: 70-71.
  • Loncar R, Stoldt V, Hellmig S, Zotz RB, Mihalj M, Scharf RE. (2007) HPA-1 polymorphism of alphaIIbbeta3 modulates platelet adhesion onto immobilized fibrinogen in an in-vitro flow system. Thromb J., 5:2.
  • Loncar R, Kalina U, Stoldt V, Thomas V, Scharf RE, Vodovnik A. (2006) Antithrombin significantly influences platelet adhesion onto immobilized fibrinogen in an in-vitro system simulating low flow. Thromb J., 4:19.
  • Stoldt VR, Schnorr O, Schulze-Osthoff K, Scharf RE. (2006) Transforming growth factor-beta1 enhances the antifibrinolytic and prothrombotic state of growing endothelial cells in a cell cycle-specific manner. FASEB J., 20:965-6.
  • Stoldt VR, Sonneborn A, Leuker CE, Ernst JF. (1997) Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J., 16:1982-91.

Cooperators

  • Schulze-Osthoff, Klaus, Prof. Dr., Eberhard Karls University Tuebingen, Germany
  • Glassmann, Alexander, Dr., Rheinische Friedrich Wilhelms University Bonn, Germany
  • Loncar, Robert, PD Dr., Heinrich Heine University Duesseldorf, Germany
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