Schmitt Group

Group leader

Title

Name

First Name

Position

Prof. Dr.

Schmitt

Lutz

Head of the Institute

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Researchers

Title

Name

First Name

Position

Dr.

Schulte

Ulrich

Senior scientist

Dr.

Hanekop

Nils

PostDoc

Dr.

Smits

Sander

Senior scientist

Dr.

Patrik

Bakkes

Post Doc


BioStruct Fellow

Title

Name

First Name

Position

Dipl.-Biol.

Meyer

Tatu

PhD student

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Further Team Members

Technicians:

3

Master/Diploma students:

6

PHD/MD students:

10


Contact

Lutz Schmitt
Institute of Biochemistry
Heinrich Heine University
Universitaetsstr. 1
40225 Duesseldorf

Tel : +49 211 81-10773
Fax: +49 211 81-15310

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Contact 2

Sander Smits

Tel : +49 211 81-12647
Fax: +49 211 81-15310

 

Expertise in Structural Biology

  • X-ray crystallography
  • Fluorescence Spectroscopy

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Main areas of research interest

  • Structure and function of ABC-transporters
  • Transport processes across biological membranes
  • Protein-protein interaction
  • Protein structure
  • Recognition processes at membranes

Facilities

The laboratories cover the following gene technology security levels:

S1

Other security laboratories or special facilities:

  • Radioactive laboratory

Laboratory Equipment

General equipment available in the laboratories:

  • Biochemistry
  • Biophysics
  • Molecular biology
  • Microbiology


Special equipment, which is not generally available in most laboratories:

  • X-ray Generator
  • Crystallization Robot
  • ITC Setup


Non-standard methods, which are established in the laboratory

  • In vitro translation
  • Incorporation of non-natural amino acids

Important References

  • L. Schmitt, H. Benabdelhak, M. A. Blight, I. B. Holland & M. T. Stubbs (2003) Crystal structure of the NBD of the ABC-transporter HlyB: Identification of a variable region within the ABC helical domains, J. Mol. Biol. 330 333-343.
  • J. Zaitseva, S. Jenewein, T. Jumpertz, I. B. Holland, & L. Schmitt (2005) H662 is the linchpin in ATP hydrolysis of the nucleotide-binding domain of the ABC-transporter HlyB, EMBO J. 24 1901-1910.
  • J. Zaitseva, C. Oswald, T. Jumpertz, S. Jenewein, A. Wiedenmann, I. B. Holland & L. Schmitt (2006) A structural analysis of asymmetry required for catalytic activity in an isolated ABC-ATPase domain dimer. EMBO J. 25 3432- 3443.
  • C. Horn, S. Jenewein, B. Tschapek, W. Bouschen, S. Metzger, E. Bremer & L. Schmitt (2008) Monitoring conformational changes during the catalytic cycle of OpuAA, the ATPase subunit of the ABC-transporter OpuA from Bacillus subtilis, Biochem. J., 412 233- 244.
  • R. Ernst, P. Kueppers, C. Klein, T. Schwarzmueller, K. Kuchler & L. Schmitt (2008) A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5 Proc. Natl. Acad. Sci USA 105 5069-5074.

Cooperators

  • Holland, Barry, Prof. Dr., University of Paris-Sud, Orsay, France
  • Kuchler, Karl, Prof. Dr., Medical University of Vienna, Austria
  • Dötsch, Volker, Prof. Dr., University of Frankfurt, Germany
  • Driessen, Arnold, Prof. Dr., University of Groningen, Netherlands
  • Volkmer, Andreas, Dr., University of Stuttgart, Germany
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