Oesterhelt Group

Group leader

Title

Name

First Name

Position

Akad. Rat Dr.

Oesterhelt

Filipp

Group leader

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Researchers

Title

Name

First Name

Position

Dr.

N.N.

Postdoc

Dr.

N.N.

Postdoc

N.N.

Doctoral Researcher


BioStruct Fellow

Title

Name

First Name

Position

N.N.

Doctoral Researcher

MSc

Roychoudhury

Arpita

Doctoral Researcher

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Further Team Members

Technicians:

1

Master/Diploma students:

1

PHD/MD students:

3


Contact

AG Nanoanalytik
Institut für Physikalische Biologie
Heinrich Heine Universität Düsseldorf
Universitätsstr. 1
40225 Düsseldorf

Tel : +49 211 81-13805

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Expertise in Structural Biology

  • Atomic Force Microscopy
  • Force Spectroscopy
  • Single Molecule Fluorescence Spectroscopy

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Main areas of research interest

  • Membrane protein structure and stability
  • Forces of ABC transporters
  • Protein - RNA interactions
  • nanopatterning of surfaces via nano-manipulation

Laboratory Equipment

General equipment available in the laboratories:

  • Biophysics
  • Imaging


Special equipment, which is not generally available in most laboratories:

  • Time resolved multi colour fluorescence detection setup
  • CCD Camera for fluorescence detection with single molecule sensitive
  • Atomic Force Microscope with simultaneous fluorescence detection (CCD camera)

Important References

  • A. Woźniak, G. Schröder, H. Grubmüller, C. Seidel, F. Oesterhelt, " Single molecule FRET measures bends and kinks in DNA" PNAS, in press
  • D.Cisneros, L. Oberbarnscheidt, A. Pannier, J. Klare, J. Helenius, M. Engelhard, F. Oesterhelt, D. J. Müller "Transducer binding establishes localized interactions that tune sensory rhodopsin II" Structure, Structure (2008) 16, 1206-13
  • V. Kudryavtsev, S. Felekyan, A. Woźniak, M. König, C. Sandhagen, R. Kühnemuth, C. Seidel, F. Oesterhelt, "Multiparameter Fluorescence Imaging to Monitor Dynamic Systems". Anal Bioanal Chem (2007) 387, 71-82.
  • A. Wozniak, S. Nottrott, E. Kühn-Hölsken, G. Schröder, H. Grubmüller, R. Lührmann, C. Seidel, F. Oesterhelt, "Detecting protein-induced folding of the U4 snRNA kink-turn by single-molecule multiparameter FRET measurements" RNA (2005) 11, 1545-1554.
  • F. Oesterhelt, D. Oesterhelt, M. Pfeiffer, A. Engel, H. E. Gaub, D. J. Müller, "Unfolding pathways of individual Bacteriorhodopsins" Science (2000) 288, 143-146

Cooperators

  • Müller, Daniel, Prof. Dr., University of Dresden, Germany
  • Engelhard, Martin, Prof. Dr., Max Planck Institute for molecular physiology, Dortmund, Germany
  • Rodnina, Marina, Prof. Dr., Max Planck Institute for biophysical Chemistry, Göttingen, Germany
  • Wintermeier, Wolfgang, Prof. Dr., University Witten Herdecke, Germany
  • Piehler, Jacob, Prof. Dr., University Osnabrück
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