Münk Group

Group leader

Title

Name

First Name

Position

Prof. Dr.

Münk

Carsten

Group Leader

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Researchers

Title

Name

First Name

Position


BioStruct Fellow

Title

Name

First Name

Position

MSc

Jaguva Vasudevan

Ananda Ayyappan

PhD student

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Further Team Members

Technicians:

1

Master/Diploma students:

1

PHD/MD students:

4


Contact

AIDS Research Group
Clinic for Gastroenterology, Hepatology and Infectiology
University Hospital Düsseldorf
Heinrich Heine University Düsseldorf
Universitätsstr. 1
40225 Düsseldorf
Germany

Tel : +49 211 81-10887

Special Methodical Expertise

  • Tissue culture of primary T cells and macrophages
  • Quantification of HIV-replication by sensitive viral and cellular reporter systems

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Main areas of research interest

  • Structure and function of APOBEC3 proteins
  • Evolution of retroviruses and co-evolution of antiviral genes
  • Innate and intrinsic immunity against HIV-1
  • Generation of animal models for HIV-1 infection

Facilities

The laboratories cover the following gene technology security levels:

S2, S3

Other security laboratories or special facilities:

  • radioactive laboratory
  • animal facility (mouse and monkey)

Laboratory Equipment

General equipment available in the laboratories:

  • Biochemistry
  • Cell biology
  • Imaging
  • Cell culture
  • Microbiology
  • Molecular biology
  • Biocomputing


Non-standard methods, which are established in the laboratory:

  • Confocal microscopy

Important references

  • Carsten Münk, T. Beck, J. Zielonka, A. Hotz-Wagenblatt, S. Chareza, M. Battenberg, J. Thielebein, K. Cichutek, I. G. Bravo, S. J. O’Brien, M. Löchelt*, and N. Yuhki*. 2008. Functions, Structure, and Read-Through Alternative Splicing of Feline APOBEC3 Genes. Genome Biology, 9 (3): R48
  • Heide Muckenfuss, M. Hamdorf, U. Held, M. Perkovic, J. Löwer, K. Cichutek, E. Flory G. G. Schumann*, and C. Münk*. 2006. APOBEC3 proteins inhibit human LINE-1 retrotransposition. The J. of Biol. Chem. 281(31): 22161-22172.
  • Martin Löchelt*, F. Romen, P. Bastone, H. Muckenfuss, N. Kirchner, Y. Kim, U. Truyen, U. Rösler, M. Battenberg, A. Saib, E. Flory, K. Cichutek, and C. Münk*. 2005. The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein. Proc. Natl. Acad. Sci. USA 102: 7982 – 7987.
  • Roberto Mariani, D. Chen, B. Schröfelbauer, F. Navarro, R. König, B. Bollman, C. Münk, H. Nymark-McMahon, and N. R. Landau. 2003. Species-specific exclusion of APOBEC3G from HIV-1 virions by VIF. Cell 114 (1):21-31.
  • Carsten Münk, S. M. Brandt, G. Lucero, N. R. Landau. 2002. A dominant block to HIV replication at reverse transcription in simian cells. Proc. Natl. Acad. Sci. USA 99: 13843 – 13848.

Cooperators

  • Schneider, Gisbert, Prof. Dr., University of Frankfurt, Germany
  • Löchelt, Martin, Prof. Dr., German Cancer Research Institut, Germany
  • Ignacio Bravo, Prof. Dr., University of Münster, Germany
  • Simon, Viviana, Prof. Dr., Mt. Sinai Hospital New York, USA
  • Kootstra, Neeltje, Dr. , University Amsterdam, The Netherlands
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