Prof. Dr. Lutz Schmitt

Photo of Lutz  Schmitt

Prof. Dr. Lutz Schmitt

Universitätsstraße 1
Building: 26.42
Floor/Room: 03.27
40225 Düsseldorf
Phone +49 211 81-10773
Fax +49 211 81-15310

Curriculum Vitae & Publications

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Expertise in Structural Biology

  • X-ray crystallography
  • Fluorescence Spectroscopy

Main areas of research interest

  • Structure and function of ABC-transporters
  • Transport processes across biological membranes
  • Protein-protein interaction
  • Protein structure
  • Recognition processes at membranes

Research Group and Equipment

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BioStruct Research Project

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Important references

  • L. Schmitt, H. Benabdelhak, M. A. Blight, I. B. Holland & M. T. Stubbs (2003) Crystal structure of the NBD of the ABC-transporter HlyB: Identification of a variable region within the ABC helical domains, J. Mol. Biol. 330 333-343.
  • J. Zaitseva, S. Jenewein, T. Jumpertz, I. B. Holland, & L. Schmitt (2005) H662 is the linchpin in ATP hydrolysis of the nucleotide-binding domain of the ABC-transporter HlyB, EMBO J. 24 1901-1910.
  • J. Zaitseva, C. Oswald, T. Jumpertz, S. Jenewein, A. Wiedenmann, I. B. Holland & L. Schmitt (2006) A structural analysis of asymmetry required for catalytic activity in an isolated ABC-ATPase domain dimer. EMBO J. 25 3432- 3443.
  • C. Horn, S. Jenewein, B. Tschapek, W. Bouschen, S. Metzger, E. Bremer & L. Schmitt (2008) Monitoring conformational changes during the catalytic cycle of OpuAA, the ATPase subunit of the ABC-transporter OpuA from Bacillus subtilis, Biochem. J., 412 233- 244.
  • R. Ernst, P. Kueppers, C. Klein, T. Schwarzmueller, K. Kuchler & L. Schmitt (2008) A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5 Proc. Natl. Acad. Sci USA 105 5069-5074.

Cooperators

  • Holland, Barry, Prof. Dr., University of Paris-Sud, Orsay, France
  • Kuchler, Karl, Prof. Dr., Medical University of Vienna, Austria
  • Dötsch, Volker, Prof. Dr., University of Frankfurt, Germany
  • Driessen, Arnold, Prof. Dr., University of Groningen, Netherlands
  • Volkmer, Andreas, Dr., University of Stuttgart, Germany
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