Prof. Dr. Holger Gohlke

Prof. Dr. Holger Gohlke

Building: 26.23.
Floor/Room: 02.32
Phone +49 211 81-13662
Fax +49 211 81-13847

Curriculum Vitae & Publications

List of Publications

Expertise in Structural Biology

  • Structural and molecular bioinformatics
  • Molecular dynamics simulations
  • Free energy calculations

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Main areas of research interest

  • Molecular recognition involving proteins and RNA as targets
  • Protein-protein interactions
  • Cotranslational processes in the ribosomal exit tunnel
  • Linking biomacromolecular structure, dynamics, and function
  • Development of structural and molecular bioinformatics tools

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Research Group and Equipment

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BioStruct Research Project

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Important references

  • Gohlke, H., Kiel, C., Case, D. A. (2003). Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes. J. Mol. Biol., 330, 891-913.
  • Gohlke, H., Thorpe, M. F. (2006). A natural coarse graining for simulating large biomolecular motion. Biophys. J., 91, 2115-2120.
  • Fulle, S., Gohlke, H., (2008). Analyzing the flexibility of RNA structures by constraint counting. Biophys. J., 94, 4202-4219.
  • Radestock, S., Gohlke, H. (2008). Exploiting the link between protein rigidity and thermostability for data-driven protein engineering. Eng. Life Science, 8, 507-522.
  • Fulle, S., Gohlke, H. (2009). Statics of the ribosomal exit tunnel: Implications for co-translational peptide folding, elongation regulation, and antibiotics binding. J. Mol. Biol., 387, 502-517.

Cooperators

  • Grez, Manuel, Dr., Georg-Speyer-Haus, Frankfurt, Germany
  • Engels, Joachim, Prof. Dr., Goethe-University, Frankfurt, Germany
  • Schwalbe, Harald, Prof. Dr., Goethe-University, Frankfurt, Germany
  • Thorpe, Mike, Prof. Dr., Arizona State University, Tempe, AZ, USA
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