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Prof. Dr. Michael Bott & Dr. Melanie Brocker

Photo of Melanie  Brocker

Dr. Melanie Brocker

Forschungszentrum Jülich GmbH
Wilhelm-Johnen-Strasse
52428 Jülich
Phone +492461-61-5168
Fax +492461-61-2710

Photo of Michael  Bott

Prof. Dr. Michael Bott

Forschungszentrum Jülich GmbH
Wilhelm-Johnen-Strasse
52428 Jülich
Phone +492461-61-3294
Fax +492461-61-2710

Curriculum Vitae

Curriculum Vitae & Publications

List of Publications

Special Methodical Expertise

  • Transcriptomics using DNA microarray technology
  • Proteomics including MALDI-TOF mass spectrometry
  • Metabolic engineering

Main areas of research interest

  • Elucidation of regulatory networks and mechanisms in biotechnologically relevant bacteria by studying transcriptional regulators, two-component signal transduction systems and serine/threonine protein kinases.
  • Analysis of the energy metabolism in biotechnologically relevant bacteria by studying the respiratory chain and ATP-generating reactions.
  • Development of microbial producer strains for amino acids, organic acids and other metabolites of industrial relevance using metabolic engineering

Research Group and Equipment

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BioStruct Research Project

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Important references

  • Kaspar, S., Perozzo, R., Reinelt, S., Meyer, M., Pfister, K., Scapozza, L., and Bott, M. (1999) The periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor. Mol. Microbiol. 33, 858-872.
  • Niebisch, A. and Bott, M. (2003). Purification of a cytochrome bc1-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunit of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1. J. Biol. Chem. 278: 4339-4346.
  • Wennerhold, J., Krug, A. and Bott, M. (2005). The AraC-type regulator RipA represses aconitase and other iron proteins from Corynebacterium under iron limitation and is itself repressed by DtxR. J. Biol. Chem. 280, 40500-40508
  • Niebisch, A., Kabus, A., Schultz, C., Weil, B. and Bott, M. (2006). Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein. J. Biol. Chem. 281, 12300-12307
  • Frunzke, J., Engels, V., Hasenbein, S., Gätgens, C. and Bott, M. (2008). Coordinated regulation of gluconate catabolism and glucose uptake in Corynebacterium glutamicum by two functionally equivalent transcriptional regulators, GntR1 and GntR2. Mol. Microbiol. 67, 305-322

Cooperators

  • Eikmanns, Bernd, Prof. Dr., University of Ulm, Germany
  • Bramkamp, Marc, Dr., University of Cologne, Germany
  • Wendisch, Volker, Prof. Dr., University of Münster, Germany
  • Burkovski, Andreas, Prof. Dr., University of Erlangen-Nürnberg, Germany
  • Pohl, Ehmke, Dr., University of Durham, U.K.
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