Prof. Dr. Heike Brötz-Oesterhelt

Prof. Dr. Heike Brötz-Oesterhelt

Heinrich-Heine-Universität Düsseldorf
Universitätsstr. 1
Building: 26.32
Floor/Room: U1.82
40225 Düsseldorf
Phone +49 211 81-14180
Fax +49 211 81-11923

Special Methodical Expertise

  • Evaluation of antibacterial activity
  • Antibiotic mechanism of action analysis
  • Bacterial molecular genetics
  • Cytotoxicity assays for eukaryotic cells

Main areas of research interest

  • Molecular mechanisms of antibiotic action
  • Novel antibacterial targets
  • Novel lead structures for antibiotic drug discovery
  • Antibiotic resistance

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Important references

  • Müller, A., Münch, D., Schmidt, Y., Reder-Christ, K., Schiffer, G., Bendas, G., Gross, H., Sahl, H.-G., Schneider, T. & Brötz-Oesterhelt, H. (2012)
    The lipodepsipeptide empedopeptin inhibits cell wall biosynthesis through Ca2+-dependent complex formation with peptidoglycan precursors. J. Biol. Chem. (epubl. ahead of print).
  • Sass, P., Josten, M., Famulla, K., Schiffer, G., Sahl, H.-G., Hamoen, L. & Brötz-Oesterhelt, H. (2011)
    Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Proc. Natl. Acad. Sci. 108, 17474-17479.
  • Lee, B.-G., Park, E. Y., Lee, K.-E., Jeon, H., Sung, K. H., Paulsen, H., Rübsamen-Schaeff, H., Brötz-Oesterhelt, H. & Song, H. K. (2010)
    Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nat. Struct. Mol. Biol. 17, 471-478.
  • Kirstein, J., Hoffmann, A., Lilie, H., Schmidt, R., Rübsamen-Waigmann, H., Brötz-Oesterhelt, H., Mogk A. & Turgay K. (2009)
    The antibiotic ADEP reprograms ClpP, switching it from a regulated to an uncontrolled protease. EMBO Mol. Med. 1, 37-49
  • Brötz-Oesterhelt, H., Beyer, D., Kroll, H.-P., Endermann, R., Ladel, C., Schroeder, W., Hinzen, B., Raddatz, S., Paulsen, H., Henninger, K., Bandow, J. E., Sahl H.-G. & H. Labischinski. (2005).
    Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat. Med. 11, 1082-1087.

Cooperators

  • Sahl, Hans-Georg, Prof. Dr., University of Bonn, Bonn, Germany
  • Song, Hyun-Kyu, Prof. Dr., University of Korea, Seoul, Korea
  • Leendert Hamoen, Dr., University of Newcastle, Newcastle, U.K.
  • Bandow, Julia, Jun. Prof. Dr., University of Bochum, Bochum, Germany
  • Alfred Goldberg, Prof. Dr., Harvard University, Boston, USA
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