Ms. Arpita Roychoudhury

Photo of Arpita  Roychoudhury

Arpita Roychoudhury M.Sc.

AG Häussinger
c/o Oesterhelt Group
Institute for Physical Biology
Heinrich-Heine-University
Universitätsstr.1
Building: 26.12
Floor/Room: U1.78
40225 Düsseldorf
Phone +49 211 81-15966

Mini Academic CV

University degrees:

First degree or intermediate examination:

  • BSc (Botany, Zoology, Chemistry), 2005, Assam University, Silchar, India

Second degree and/or intermediate examination:

  • MSc (Biotechnology), 2007, Assam University, Silchar, India

Further degrees and/or interemediate examinations:

  • BEd (Bachelor of Education), 2008, Assam University, Silchar, India

Publications:

  • “Computer Aided Drug Designing – pros and cons” in The Journal of Biotechnology Vol 1, in 2008, G.C. College
  • “How many genes are there?” in THE JOURNAL OF BIOTECHNOLOGICAL SOCIETY OF BARAK VALLEY, Volume 2 in 2006
  • "Human Genome Project – Hope and Fear” in BIOVISION , Volume 6 annual science magazine of Department of Zoology, G.C.College, Silchar , Assam in 2005
  • “Rosalind Franklin and Fifty years of Discovery of DNA” Volume 5 annual science magazine of Department of Zoology, G.C.College, Silchar , Assam in 2004

Attended conferences:

  • Seminar on “Biotechnology for social Welfare” organized by Biotechnological Society of Barak Valley in collaboration with Department of Biotechnology, Assam University, Silchar on May 16, 2006
  • “Biodiversity workshop” organized by the School of Life Sciences, University of Hyderabad, Hyderabad on World Biodiversity Day, 22nd May, 2007
  • “Workshop on Research Methodology in Basic Sciences” held from 13 to 17 November, 2006 at Assam University, Silchar
  • Attended the seminar on “ Applications of Biotechnology in Biological Resource Welfare” organized by Biotechnological Society of Barak Valley in collaboration with Department of Biotechnology, Assam University, Silchar on August 9, 2005

Prices/Scholarships:

  • First Class First in MSc ( Biotechnology) - Gold medal, Merit prize and Endowment prize
  • First Class First in BSc. (Zoology major) - Merit prize
  • First Class First in BEd (Bachelor of Education) - Gold medal and merit prize
  • First prize in Regional Science Exhibition on the topic - Transgenic Breeds and their uses
  • Rank Certificate in National Science Olympiad
  • Assam Junior Basic Scholarship for 3 years
  • Award for securing 76% in General Knowledge and 74% in Science in National Talent Search Contest

BioStruct PhD project

Compatible solute induced structural changes in membrane proteins that correlate with the modulation of protein function
In nature, compatible solutes (organic osmolytes) are used for protecting cells against high osmotic stress. They are known also to stabilize protein structures and support protein folding. Compatible solutes displace the solvent molecules, thereby affecting protein folding.
We want to understand whether biological effects on the cellular level induced by an increase or decrease in the solute level, respectively, may be explained by the direct interaction of the compatible solutes with the membrane proteins under investigation. We will test the effect of compatible solutes (e.g.betaine, taurine and ectoine) on stability and folding of different membrane proteins like Bacteriorhodopsin and membran transporters. Using Atomic Force Microscopy and Force Spectroscopy we will investigate the effects in presence and absence of the osmolytes: first, stabilization of secondary structure elements of the membrane proteins by forced unfolding experiments. Second, stiffening of the unfolded amino acid chains due to solvent binding by measuring the polymer elasticity. Third, visualizing structural changes in the unfolded parts of the inner and outer loops of the respective proteins by high resolution imaging. Fourth, observing variations in the folding pathway with force guided refolding experiments.

Supervisors

Topic Supervisor:

undefinedProf. Dr. Dieter Häussinger, Clinic for Gastroenterology, Häussinger Group

Complementary Supervisor:

undefinedProf. Dr. Filipp Oesterhelt, Institute for physical Chemistry II, Oesterhelt Group

Complementary Supervisor:

PD Dr. Roland Reinehr, Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf

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