Antony Sravan Kumar Yerabham

Photo of Antony Sravan Kumar Yerabham

Antony Sravan Kumar Yerabham M.Sc.

Institute for Neuropathology
Heinrich Heine Universität Düsseldorf
Moorenstraße 5
Building: 14.79
Floor/Room: 03.416
40225 Düsseldorf
Phone +49 211 81-1865

Mini Academic CV

University degrees:

First degree or intermediate examination:

  • Bachelor of Science (B.Sc.), 2007, Osmania University, Government City College, Hyderabad, India.

Second degree and/or intermediate examination:

  • Master of Science (M.Sc.), 2010, University of Hyderabad, Hyderabad, India.

Attended conferences:

  • Attended the conference "From Innovations in Nucleic Acids Research to Regulation of Biological Processes" (FINAR2RBP), held from December 17-19, 2011, in Indian Institute of Science (IISc), Bengaluru, India.
  • Attended the 40th National Seminar on Crystallography, held from November 26-28, in Osmania University, Hyderabad, India.

Prices/Scholarships:

  • Secured All India 141th Rank in Graduate Aptitude Test in Engineering (GATE) examination with a percentile of 98.7 in 2011.
  • Qualified Council for Scientific and Industrial Research (CSIR) Junior Research Fellowship in 2009 & 2010; the nationwide competitive test for pursuing PhD in India.
  • Junior Research Fellowship (project), Centre for Cellular and Molecular Biology, Hyderabad, India from September 2010 - August 2012.
  • Received Achiever's award for meritorious students in M.Sc(1st Semester) during July 2008.

BioStruct PhD project

Structural studies on molecular interactions of the Disrupted-in-schizphrenia (DISC1) protein

The molecular causes of schizophrenia are still unknown. Based on several genetic studies, the disrupted-in-schizophrenia 1 (DISC1) protein has come into focus for investigating molecular mechanisms of schizophrenia and other mental diseases. DISC1 is a well established genetic risk factor for a spectrum of psychiatric disorders, having an extensive interaction capability but lacks an enzymatic activity. Thus its protein interaction network is an attractive target for probing into its mechanistic details but there is a relative deficit in the structural information to connect it to the myriad of biological functions.

Here, we focus on pursuing structural and quantitative investigations of DISC1 and few of its interacting proteins, which by themselves are standalone mental risk factors, like NDE1, NDEL1, LIS1 and PDE4B. Structural studies are being extensively attempted by crystallography for the single and complexed proteins or their soluble representative fragments overexpressed in E.coli. This is further complemented by binding studies and mutational analyses.

These investigations will yield insights into stoichiometry and regulation of interactions in the DISC1/ NDE1/ NDEL1/ LIS1/ PDE4B complex. Thus structural determination of the binding interfaces will open novel pharmacological targets for various mental illnesses.

Supervisors

Topic Supervisor:

undefinedProf. Dr. med. Carsten Korth, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Korth Group

Complementary Supervisor:

undefinedPD. Dr. Reza Ahmadian,

Responsible for the content: E-MailBioStruct Office