Ananda Ayyappan Jaguva Vasudevan

Photo of Ananda Ayyappan Jaguva Vasudevan

Ananda Ayyappan Jaguva Vasudevan M.Sc.

Münk Group
Clinic for Gastroenterology, Hepatology and Infectiology
Heinrich Heine University
Moorenstr. 5
Building: 23.12
Floor/Room: U1.87
40225 Düsseldorf
Phone +49 211 81-10889
Fax +49 211 81-15431

Mini Academic CV

University degrees:

First degree or intermediate examination:

  • B.Sc.(Biochemistry), 2006, Madurai Kamaraj University, Sourashtra College, Madurai, India

Second degree and/or intermediate examination:

  • M.Sc.(Biotechnology), 2008, Madurai Kamaraj University, Sourashtra College, Madurai, India

Further degrees and/or interemediate examinations:

  • Advanced Diploma in Biotechnology, 2008, Madurai Kamaraj University, Sourashtra College, Madurai, India

Attended conferences:

  • ”Molecular Modelling, Drug Designing-Docking studies in Spermidine Synthase in Plasmodium falciparum” Orally presented at a National level Symposium, “BIO &alpha ’08”, SRM University ,Kanchipuram, Tamilnadu, India, 2008
  • Prebiotics and Probiotics as Therapeutical agents: Orally presented at a two days National Level Conference on “Future Scenario of Biosciences”, Namakkal, Tamilnadu, India, 2006
  • ””Molecular Modelling of Plasmepsin protein” Orally presented in a National level Symposium, Bioinformatics-“Mofif-05”, Bharathiyar University, Coimbatore, Tamilnadu, India, 2007
  • International Conference on Open Source for Computer Aided Drug Discovery held at IMTECH (March, 2009), Chandigarh, India.
  • Undergone Training Programme in the Division of Cancer Research, Regional Cancer Centre (RCC), Thiruvananthapuram for a period of 15days from 18th June 2007 to 02 July 2007
  • Participated in 2 weeks Industrial Training program on Drug Discovery and Drug Target Identification in SAI Biosciences Research Institute Pvt Ltd., Chennai, India, from 21st May 2007 to 4th June 2007
  • Served as an Assistant Resource person in Workshop and Seminar on Tools and Applications on Genomics and Proteomics in S.V.N arts and science colleges of Madurai, Tamilnadu, India, 2008
  • Participated in the District RYLA (Rotary Youth Leadership Award), Dindigul, Tamilnadu, India 2005
  • Participated in “HORIZON 2006”-14th National level Students Symposium on Nanoparticles in National institute of technology, Trichy, Tamilnadu, India
  • National Conference on “Advances in Solid Waste Management”, Gandhigram Rural Institute-Deemed University
  • Two days National Symposium on “Herbal Science-Research and Industry Perspective” in Kamaraj College of Engineering and Technology, Virudhunagar, Tamilnadu, India
  • Fifth National level Biological Congress on “Biotechnology-A Global Perspective”, organized by Muthayammal college of Arts and Science, Rasipuram, Tamilnadu, India
  • Attended and served as an Assistant Trainer for the 10 days National Workshop on “Advanced Techniques in Biotechnology” in Sourashtra College, Madurai, Tamilnadu, India
  • BioStruct MasterClasses 2010 and 2011
  • Various University conducted national level seminars in India during college studies

 

Prices/Scholarships:

  • 1st prize, Poster Presentation: Advancements in Genetic Engineering and Featherless Chicken, State level Seminar on “Modern trends in Biological Sciences” in V.V.Vaniaperumal College for Women, Virudhunagar, Tamilnadu, India, 2004
  • Gold Medal for Excellence in Bachelor and Master degrees
  • Silver Medal in XI standard for securing School first mark in Tamil Language
  • Madurai Kamaraj University Rank IV in Bachelor degree
  • 3rd prize, Paper Presentation: Prebiotics and Probiotics as Therapeutical agent, National level seminar on “Future Scenario of Biosciences”, at Biogeneic-An institute of biotechnology, Namakkal, Tamilnadu, India, 2006
  • Recipient of “North South Foundation-BREAD (Basic Research, Education and Development) Scholarship” in Bachelor degree, 2003
  • Recipient of NRW research school, "Biostruct" stipend (02/2010- 02/2013)
  • Secured Young Investigator Award to attend CROI meeting at Atlanta, March 2013


Publications:

  • Kopietz F, Jaguva Vasudevan AA, Krämer M, Muckenfuss H, Sanzenbacher R, Cichutek K, Flory E, Münk C . Interaction of human immunodeficiency virus type 1 Vif with APOBEC3G is not dependent on serine/threonine phosphorylation status
  • Jaguva Vasudevan, A. A., Smits, S. H., Hoppner, A., Haussinger, D., Koenig, B. W., and Munk, C. (2013) Structural features of antiviral DNA cytidine deaminases, Biological chemistry 394, 1357-1370.
  • Jaguva Vasudevan, A. A., Perkovic, M., Bulliard, Y., Cichutek, K., Trono, D., Haussinger, D., and Munk, C. (2013) Prototype foamy virus Bet impairs the dimerization and cytosolic solubility of human APOBEC3G, Journal of virology 87, 9030-9040.
  • Horn, A.V., Klawitter, S., Held, U., Berger, A., Jaguva Vasudevan, A. A., Bock, A., Hofmann, H., Hanschmann, K. M., Trösemeier, J. H., Flory, E., Jabulowsky, R.A., Han, J. S., Löwer, J., Löwer, R., Münk, C., and Schumann, G. G. (2013)  Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by          an ORF1p interaction that affects LINE reverse transcriptase activity, Nucleic Acids Research.
  • Kopietz, F., Jaguva Vasudevan, A. A., Kramer, M., Muckenfuss, H., Sanzenbacher, R., Cichutek, K., Flory, E., and Munk, C. (2012) Interaction of human immunodeficiency virus type 1 Vif with APOBEC3G is not dependent on serine/threonine phosphorylation status, The Journal of general virology 93, 2425-2430.

 

 

BioStruct PhD project

Characterization of the HIV-1 Vif interaction site in anti-viral cytidine deaminases (APOBEC3)
HIV-1 uses its accessory protein Vif to destroy the potent intracellular inhibitors APOBEC3F and -G that are antiviral cytidine deaminases. The interaction of Vif and APOBEC3 is delicate and species-specific: e.g. the Vif protein of SIV of African green monkey fails to bind to human APOBEC3G and in consequence, humans are protected and resistant to this monkey virus. The proposed project will obtain structural and functional data of the Vif:APOBEC3 interaction, design interfering peptides to block Vif and stop the replication of HIV-1. Required work involves the generation of recombinant proteins, NMR, modelling, construction of eukaryotic expression plasmids, work with human cells and viral infection assays.

Supervisors

Topic Supervisor:

undefinedProf. Dr. Carsten Münk, Clinic for Gastroenterology, Hepatology and Infectiology, University Hospital Düsseldorf,Heinrich Heine University AIDS Research Group

Complementary Supervisor:

undefinedProf. Dr. Dieter Willbold, Institute of Physical Biology, Heinrich Heine University, Düsseldorf, Willbold Group

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